Ventoux AOC (formerly Côtes du Ventoux AOC) is a wine-growing AOC in the southeastern region of the Rhône wine region of France, where the wines are produced in 51 communes of the Vaucluse département along the lower slopes of the Ventoux mountain, the northernmost peak of the Luberon range.

The neighbouring appellation of Côtes du Luberon AOC stretches along its southern border and is separated from it by the Calavon river.

The three main areas of the region, the Malaucène basin, the foothills of the Mont Ventoux to the east of Carpentras and to the north of Cavaillon are less ravaged by the Mistral due to some shelter afforded by the Ventoux-Vaucluse-Luberon mountain range.

Archeological discoveries of wine making equipment have dated that wine has been produced in the area at least since around 30 AD.